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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIKFYVE
All Species:
20
Human Site:
S1566
Identified Species:
48.89
UniProt:
Q9Y2I7
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2I7
NP_055855.2
2098
237108
S1566
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Chimpanzee
Pan troglodytes
XP_516057
2098
237088
S1566
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Rhesus Macaque
Macaca mulatta
XP_001108540
2098
237142
S1566
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Dog
Lupus familis
XP_536048
2100
237099
S1568
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1T6
2097
236858
S1565
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508087
1539
172614
R1016
E
L
K
D
L
E
S
R
R
K
K
Q
L
L
R
Chicken
Gallus gallus
XP_421967
2112
239039
Q1580
F
L
T
T
L
S
S
Q
S
S
T
G
S
T
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96838
1809
204617
L1286
S
K
V
T
T
S
S
L
P
K
E
N
D
P
L
Honey Bee
Apis mellifera
XP_393666
1986
224732
D1452
S
N
S
I
I
D
T
D
G
Y
I
T
E
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P34756
2278
257401
S1733
E
A
P
V
G
E
H
S
R
A
N
N
C
N
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.1
95.2
N.A.
93.5
N.A.
N.A.
53.9
86.2
N.A.
N.A.
N.A.
28.7
34.1
N.A.
N.A.
Protein Similarity:
100
99.9
99.4
97
N.A.
96.3
N.A.
N.A.
60.2
91.5
N.A.
N.A.
N.A.
46.1
53.5
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
0
6.6
N.A.
N.A.
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
13.3
33.3
N.A.
N.A.
N.A.
33.3
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
50
0
0
10
0
10
0
10
0
0
0
0
10
10
0
% D
% Glu:
20
0
0
0
0
20
0
0
0
0
10
0
10
0
0
% E
% Phe:
10
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
0
10
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
10
10
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
10
10
0
0
0
0
0
0
20
10
0
0
0
0
% K
% Leu:
0
20
0
50
20
0
50
10
0
0
0
0
10
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
10
20
0
10
0
% N
% Pro:
0
0
10
0
0
0
0
0
10
0
0
0
0
10
10
% P
% Gln:
0
0
0
0
0
0
0
10
0
50
0
10
0
0
0
% Q
% Arg:
0
50
0
0
0
0
0
10
20
0
0
0
0
0
10
% R
% Ser:
20
0
10
0
0
20
30
60
60
10
50
50
10
50
50
% S
% Thr:
0
0
10
20
60
50
10
0
0
0
10
10
50
10
10
% T
% Val:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _